Prolozone and PRP Therapy

What is Prolozone?

Prolozone is the use of natural substances as well as local anesthetic agents in conjunction with ozone, which helps to repolarize injured cell membranes, improve circulation, reduce inflammation, reduce edema, reverse acidosis, improve glucose utilization, supplies mitochondrial substrates, improves oxygen utilization, stimulate cytokines, and kill microbes.

How does Prolozone Work?

Prolozone works by stimulating the body’s regenerative potential and therefore compliments all other regenerative treatments including stem cell therapy and PRP.


Ozone Therapy, Inc

Study:

Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials

Conclusion:

In terms of pain reduction and function improvement, prolotherapy with hypertonic dextrose was more effective than infiltrations with local anesthetics, as effective as infiltrations with hyaluronic acid, ozone or radiofrequency and less effective than PRP and erythropoietin, with beneficial effect in the short, medium and long term. In addition, no side effects or serious adverse reactions were reported in patients treated with hypertonic dextrose. Although HDP seems to be a promising interventional treatment for knee OA, more studies with better methodological quality and low risk of bias are needed to confirm the efficacy and safety of this intervention.

Adv Rheumatol. 2019 Aug 19;59(1):39.

Platelet-Rich Plasma (PRP):

What is PRP, and how is it prepared?

Platelet-Rich Plasma (PRP) is prepared by taking a few tubes of your own blood and spinning it through a centrifuge to concentrate the platelets. Once concentrated, these activated platelets are then injected directly into your injured body tissue. This releases growth factors that stimulate and increase the number of reparative cells your body produces.

Platelet-Rich Plasma (PRP) in Orthopedic Sports Medicine:

The use of platelet-rich plasma (PRP) injections in the treatment of musculoskeletal conditions has become more prevalent in recent years. Current literature has exhibited that PRP injections are relatively safe and can potentially accelerate or augment the soft tissue healing process. This review presents the most current literature update on the use of PRP in the treatment of rotator cuff tears, osteoarthritis of the knee, ulnar collateral ligament tears, lateral epicondylitis, hamstring injuries, and Achilles tendinopathy.


Am J Orthop (Belle Mead NJ)  Jul-Aug 2016;45(5):290-326